DSIP
Research highlights
- ✓Endogenous neuropeptide first isolated from rabbit cerebral venous blood
- ✓Studied for roles in sleep architecture, delta-wave sleep induction and circadian regulation
- ✓Research interest in stress response modulation and cortisol regulation pathways
- ✓Investigated for potential neuroprotective and anti-oxidative properties in research models
Read Carl's plain-English guide: DSIP on Peptide Carl ›
What is DSIP?
DSIP (Delta Sleep-Inducing Peptide) is an endogenous neuropeptide studied for its roles in sleep regulation, stress response, and neuroendocrine function.
What is the dose per vial?
10mg per vial, lyophilised powder for reconstitution.
What purity is guaranteed?
Where we hold an independent Janoshik report for a compound we publish it in full - batch number, purity and a verification key you can check against the lab yourself. Where we do not hold one the product is marked research grade and we say so, rather than claim a report we cannot produce.
DSIP, explained
The short version: DSIP (delta sleep-inducing peptide) is a nine-amino-acid peptide isolated from rabbit blood in 1977 and named for the deep sleep it seemed to trigger. When a 2006 review called it a riddle, its gene and receptor were still unknown, and the sleep link remains weak.
What it is
A group in Basel isolated DSIP in 1977 from the venous blood draining the brains of rabbits, and it was first seen as a candidate natural sleep factor. Its sequence does not match any known peptide family. Strangely for a hormone-like molecule, no gene, precursor protein or receptor for it has been identified.
What has been studied
By the mid-1980s a review in Peptides could list a long run of animal studies on sleep and on effects beyond sleep, with researchers exploring it for insomnia, pain and withdrawal. The mechanism was still unexplained.
In people, a 1992 double-blind study in Neuropsychobiology gave DSIP or placebo to 16 people with chronic insomnia over three nights. Sleep efficiency was a little higher and falling asleep a little quicker on DSIP, but the effects were weak, partly down to a chance change in the placebo group, and subjective sleep quality did not budge. The authors concluded it was unlikely to be of major benefit for chronic insomnia.
Where the evidence stops
A 2006 review in the Journal of Neurochemistry called DSIP a still unresolved riddle and described the case for it as a sleep factor as extremely poorly documented. The Moscow authors noted that in their own rabbit and rat work, some synthetic DSIP analogues promoted deep sleep but DSIP itself did not. The human work we found is small and dates from the 1980s and early 1990s.
Handling and storage
It arrives as a freeze-dried powder. Once bacteriostatic water goes in, it belongs in the fridge. Our reconstitution and storage guide covers the details, and the calculator does the maths.
Named for an effect it never convincingly showed. An interesting puzzle, not an established sleep peptide.
Sources (checked 7 October 2026)
For research use only. Not for human consumption. Nothing on this page is medical advice.
Reviews from people who ordered DSIP
No reviews from orders with DSIP yet. Here is what recent customers said about ordering from us.
★★★★★
Youre the best Thankyou!!
Rosemary V. · 8 Oct 2026
★★★★★
It was my 1st order. Everything went smooth, fantastic, fabulous!!!!! Received my vials 3days after placing the order. Asked lots of questions and received answers within minutes. Great awesome service!!! Will definitely order again. Thanks so much. Keep it up.
Lila J. · 8 Oct 2026
★★★★★
Thank you for my peptides, I received it very fast and in good order
Louise G. · 7 Oct 2026
★ 4.8 across all 19 JP Research reviews, good and bad. See them. Every reviewer gets R100 store credit, whatever they rate.
