Research & guides

The JP Research Journal

Plain-English guides to research compounds — what they are, how they differ, and what the evidence does and doesn't show. How we write and check these.

PT-141: the peptide that became Vyleesi, and the fine print
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PT-141: the peptide that became Vyleesi, and the fine print

PT-141 is bremelanotide, which the FDA approved as Vyleesi in 2019. Here is where it came from, what the two big trials…

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TB-500: a fragment with a borrowed reputation, and the fine print

TB-500 is sold on the strength of research into thymosin beta-4, a 43-amino-acid repair protein. Here is what TB-500 actually is, which…

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Epithalon: the telomere peptide, and the fine print
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Epithalon: the telomere peptide, and the fine print

Epithalon is a four-amino-acid peptide modelled on a cattle pineal extract, best known for telomere claims. Here is who did the research,…

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Uncategorized

CBL-514: the fat-cell injection in the headlines, and what the data covers

CBL-514 went viral after a diabetes conference abstract reported less visceral fat on MRI. Here is what the developer's phase 2 data…

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KPV: the anti-inflammatory tail of alpha-MSH, and the fine print
Uncategorized

KPV: three amino acids from alpha-MSH, and the fine print

KPV is three amino acids clipped from the end of alpha-MSH. Here is what the cell and mouse colitis studies found, how…

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BPC-157: a mountain of rat studies, and a very thin human file
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BPC-157: a mountain of rat studies, and a very thin human file

BPC-157 has a huge animal literature and almost nothing in people. Here is what the human record actually holds, what the FDA's…

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Semaglutide vs tirzepatide vs retatrutide: Carl’s 6/10, fixed

Peptide Carl gave our GLP-1 explainer 6/10 and we accept it. Here is the fix: semaglutide, tirzepatide and retatrutide trials, side effects…

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MOTS-c: a peptide written in mitochondrial DNA, and the fine print
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MOTS-c: a peptide written in mitochondrial DNA, and the fine print

MOTS-c is a 16-amino-acid peptide coded in mitochondrial DNA rather than the nucleus. Here is what the mouse work found, what little…

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SS-31: the peptide that reached the FDA, and the fine print
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SS-31: the peptide that reached the FDA, and the fine print

SS-31 is a four-amino-acid peptide aimed at the inner wall of the mitochondria. As elamipretide it won an accelerated FDA approval in…

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Three unlabelled glass vials of freeze-dried powder lit in violet on a reflective surface.
Guides

How Long Does a Peptide Vial Last? Storage, Stability and When to Reorder

Dry powder vs solution, fridge vs room temperature, and why there is no single shelf life: a plain guide to peptide vial…

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