5-Amino-1MQ
Research highlights
- ✓May inhibit NNMT (nicotinamide N-methyltransferase) — a key metabolic enzyme
- ✓May boost intracellular NAD+ and SAM levels
- ✓Studied for obesity, metabolic syndrome and adipogenesis suppression
- ✓Novel mechanism distinct from NMN or NR supplementation research
Read Carl's plain-English guide: 5-Amino-1MQ on Peptide Carl ›
What is 5-Amino-1MQ?
5-Amino-1MQ is a small molecule inhibitor of NNMT that may increase intracellular NAD+ levels by blocking a key catabolic pathway. It offers a distinct route to NAD+ elevation compared to NMN or NR precursors.
What purity is guaranteed?
Where we hold an independent Janoshik report for a compound we publish it in full - batch number, purity and a verification key you can check against the lab yourself. Where we do not hold one the product is marked research grade and we say so, rather than claim a report we cannot produce.
5-Amino-1MQ, explained
The short version: 5-Amino-1MQ is a small molecule, not a peptide, that blocks an enzyme called NNMT. Almost everything known about it comes from mice and cells, largely from one university lab in Texas.
What it is
The full name is 5-amino-1-methylquinolinium. It inhibits nicotinamide N-methyltransferase (NNMT), an enzyme that puts a methyl tag on nicotinamide, a building block of NAD+, and uses up SAM, the body's main methyl donor, while doing it. In fat cells, blocking NNMT with this compound lowered the enzyme's end product and raised both NAD+ and SAM. That is the link to NAD+ that our journal piece on the two digs into.
What has been studied
The target came first. A 2014 Harvard study in Nature found NNMT levels were higher in the fat and liver of obese and diabetic mice, and that switching the gene down in those tissues protected mice from diet-induced obesity by raising energy use.
A team at the University of Texas Medical Branch then built drug-like inhibitors and named 5-amino-1MQ as its lead (Biochemical Pharmacology, 2018). In diet-induced obese mice treated for 11 days, treated mice lost about 5% of body weight while controls gained about 1.4%. A white fat depot shrank by about 35% and fat cells got more than 30% smaller, with no difference in how much the mice ate.
The same lab's NNMT inhibitor was tested in 24-month-old mice with an injured leg muscle (2019). Muscle stem cells were more active, fibres grew back larger, and peak muscle force was about 70% higher than in untreated old mice.
Where the evidence stops
Mice, cells and short treatment windows, with most of the drug work coming from a single group. The Nature study used gene knockdown, not this compound. We found no human trial registered on ClinicalTrials.gov.
Handling and storage
It arrives as a freeze-dried powder. Once bacteriostatic water goes in, it belongs in the fridge. Our reconstitution and storage guide covers the details, and the calculator does the maths.
A neat enzyme target and tidy mouse results, with no human data at all.
Sources (checked 7 October 2026)
For research use only. Not for human consumption. Nothing on this page is medical advice.
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