KPV
Research highlights
- ✓C-terminal fragment of alpha-MSH with potent anti-inflammatory properties
- ✓Studied extensively in inflammatory bowel disease and gut repair models
- ✓Skin-protective effects relevant to wound healing and dermatology research
- ✓Excellent safety profile — naturally derived from endogenous hormones
What is KPV?
KPV (Lys-Pro-Val) is the C-terminal tripeptide of alpha-MSH. It reduces inflammation via NF-κB pathway inhibition and has been researched for gut inflammation, skin repair and immune modulation.
What purity is guaranteed?
Where we hold an independent Janoshik report for a compound we publish it in full - batch number, purity and a verification key you can check against the lab yourself. Where we do not hold one the product is marked research grade and we say so, rather than claim a report we cannot produce.
KPV, explained
The short version: KPV is three amino acids long: lysine, proline and valine. It is the tail end of a hormone called alpha-MSH, and it is about as small as a useful peptide gets.
What it is
Alpha-MSH is best known for skin pigment, but it also calms inflammation. KPV is the last three amino acids of that hormone, and researchers found that this tiny piece keeps much of the anti-inflammatory activity on its own.
What has been studied
In cell studies, KPV damps down NF-kB, a master switch for inflammation, and lowers inflammatory signals such as TNF-alpha and IL-6. Gut cells can take it up through a transporter called PepT1, which is why so much of the work is about the intestine.
In mouse models of colitis, KPV reduced inflammation, and a 2010s line of work packed it into nanoparticles designed to release it in the colon.
Where the evidence stops
All of it is cell culture and rodent work. As far as we can find, no human trial of KPV has been run or registered.
Handling and storage
It arrives as a freeze-dried powder. Once bacteriostatic water goes in, it belongs in the fridge. Our reconstitution and storage guide covers the details, and the calculator does the maths.
Three amino acids that carry much of a hormone's anti-inflammatory effect. Promising in mice, untested in people.
Sources (checked 7 October 2026)
For research use only. Not for human consumption. Nothing on this page is medical advice.
Reviews from people who ordered KPV
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★★★★★
Great service as always
Nico V. · 6 Oct 2026
★★★★★
I am happy with my product
Kholofelo L. · 30 Sep 2026
★★★★
Small checkout glitch, but after following up it was quickly sorted out and everything went smoothly from there. Good customer service - thank you.
Tonia K. · 30 Sep 2026
★ 4.8 across all 16 JP Research reviews, good and bad. See them. Every reviewer gets R100 store credit, whatever they rate.
