Ipamorelin
Research highlights
- ✓Highly selective GHS-R1a agonist — no cortisol or prolactin elevation
- ✓Clean GH pulse ideal for long-term secretagogue research
- ✓Synergistic when combined with CJC-1295 No DAC for combined GHRH/GHS studies
- ✓Well-characterised safety profile in published literature
Further reading: an independent guide to Ipamorelin ›
What is Ipamorelin?
Ipamorelin is a pentapeptide GH secretagogue that may selectively stimulate GH release without affecting cortisol, prolactin or ACTH — making it the cleanest secretagogue for research purposes.
What purity is guaranteed?
Where we hold an independent Janoshik report for a compound we publish it in full - batch number, purity and a verification key you can check against the lab yourself. Where we do not hold one the product is marked research grade and we say so, rather than claim a report we cannot produce.
Ipamorelin, explained
The short version: Ipamorelin is a five-amino-acid peptide that prompts the pituitary to release growth hormone. Its selling point in the research is what it does not do: it does not drag cortisol and other hormones up with it, which older peptides in its class did.
What it is
Ipamorelin is a growth hormone secretagogue: something that prompts the body to release its own growth hormone rather than being growth hormone itself. It works on the ghrelin receptor, the same switch the hunger hormone ghrelin uses.
Why "selective" matters
When Novo Nordisk researchers first described it in 1998, they called it the first selective growth hormone secretagogue. In their pig studies it released growth hormone about as strongly as the older peptide GHRP-6, but without raising ACTH or cortisol, even at doses far above the amount needed for the growth hormone effect.
| How it works | Approved medicine? | |
|---|---|---|
| Ipamorelin | Ghrelin receptor | No |
| CJC-1295 | GHRH analogue | No |
| Tesamorelin | GHRH analogue | Yes: Egrifta (US, 2010) |
What the human trial found
Ipamorelin reached a phase 2 trial for a different purpose: getting the gut moving again after bowel surgery. In 114 patients, the ipamorelin group recovered slightly faster on average, but the difference was not statistically significant, and development did not go further. It was well tolerated.
Where the evidence stops
The hormone-selectivity data comes mostly from animals, and the one sizeable human trial missed its main goal. There is no approved medicine containing ipamorelin.
Handling and storage
It arrives as a freeze-dried powder. Once bacteriostatic water goes in, it belongs in the fridge. Our reconstitution and storage guide covers the details, and the calculator does the maths.
A cleaner signal than the peptides that came before it, according to the animal work. The human trial story is more modest.
Sources (checked 7 October 2026)
For research use only. Not for human consumption. Nothing on this page is medical advice.
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Tonia K. · 30 Sep 2026
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