AOD-9604
Research highlights
- ✓Fragment of hGH (amino acids 176-191) — studied for fat-metabolising properties
- ✓May stimulate lipolysis and inhibit lipogenesis in research models
- ✓No IGF-1 stimulation — cleaner metabolic profile for isolated research
- ✓Characterised in published clinical research
Read Carl's plain-English guide: AOD-9604 on Peptide Carl ›
What is AOD-9604?
AOD-9604 is a modified fragment of human growth hormone (hGH172-191) that may retain the fat-metabolising properties of GH without activating the full GH receptor, making it useful for isolated lipolysis research.
What purity is guaranteed?
Where we hold an independent Janoshik report for a compound we publish it in full - batch number, purity and a verification key you can check against the lab yourself. Where we do not hold one the product is marked research grade and we say so, rather than claim a report we cannot produce.
AOD-9604, explained
The short version: AOD-9604 is a modified piece of the tail end of human growth hormone, developed in Australia as an obesity drug. It went through six human trials, looked safe, and did not deliver the weight loss it was built for.
What it is
AOD-9604 is a 16-amino-acid peptide. It takes positions 177 to 191 of human growth hormone, adds an extra tyrosine at the front to make it more stable, and closes a ring between its two cysteines. It grew out of Monash University work on the part of growth hormone that seemed to drive fat breakdown, and Metabolic Pharmaceuticals took it into clinical development.
It is close kin to HGH Fragment 176-191 but not the same thing. AOD-9604 is one specific, modified molecule with its own safety studies and human trials. The plain fragment never had either.
What has been studied
In obese rodents, the Monash group reported less weight gain and more fat breakdown in fat tissue. Toxicology followed in rats and cynomolgus monkeys.
Then came people. A 2013 review pooled six randomised, placebo-controlled trials. AOD-9604 did not raise IGF-1, did not worsen glucose tolerance the way full growth hormone can, triggered no antibodies in the people tested, and no serious adverse events were put down to it. The problem was efficacy: weight loss seen in earlier trials did not show up in the last, larger trial, which included an intensive diet and exercise programme. It never became an obesity medicine. It later gained GRAS (generally recognised as safe) status for use in foods and supplements, on condition that the safety data were published.
Where the evidence stops
The human trials asked one question, whether it causes fat loss, and the final answer was no better than placebo. Claims beyond that rest on rodent and tissue work. WADA names AOD-9604 on its Prohibited List as a growth hormone fragment. The trial safety record belongs to the trial material, not to research vials.
Handling and storage
It arrives as a freeze-dried powder. Once bacteriostatic water goes in, it belongs in the fridge. Our reconstitution and storage guide covers the details, and the calculator does the maths.
Six human trials, a clean safety record, and no real weight loss when it counted.
Sources (checked 7 October 2026)
For research use only. Not for human consumption. Nothing on this page is medical advice.
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Rosemary V. · 8 Oct 2026
★★★★★
It was my 1st order. Everything went smooth, fantastic, fabulous!!!!! Received my vials 3days after placing the order. Asked lots of questions and received answers within minutes. Great awesome service!!! Will definitely order again. Thanks so much. Keep it up.
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Louise G. · 7 Oct 2026
★ 4.8 across all 19 JP Research reviews, good and bad. See them. Every reviewer gets R100 store credit, whatever they rate.
